Comparative genotoxic evaluation of 2-furylethylenes and 5-nitrofurans by using the comet assay in TK6 cells
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منابع مشابه
Using Comet Assay for Genotoxic Evaluation of Zataria multiflora Boiss., An Iranian Endemic Plant
Background: Zataria multiflora Boiss. (Avishan-e Shirazi), as an Iranian endemic plant, belongs to the Lamiaceae family and may be used as a food preservative. This study aimed to detect potential genotoxic effects of Z. multiflora extract. Methods: Hydro-alcoholic extract of Z. multiflora was prepared. Human B lymphocytes were treated with 1% extract within 3 and 24 h. Sterile Phosphate Buff...
متن کاملGenotoxic and Antigenotoxic Activity of Silymarin by an In Vivo Bone Marrow Micronucleus Assay and Comet Assay
Introduction: Silymarin is obtained from Silybum marianum (milk thistle), an edible plant that has long been used medicinally for the treatment of liver-related disorders. Silymarin is a powerful hepatoprotective and antioxidant but the anticlastogenic activity, which is an important aspect of its cancer chemoprevention is not known hence the present investigation was carried out to study its...
متن کاملGenotoxic effects of oestrogens in breast cells detected by the micronucleus assay and the Comet assay.
Cumulative exposure to oestrogen has been linked to increased risk of breast cancer. Whilst oestrogens induce cancers in rodent bioassays it is unclear whether the mechanisms involved are genotoxic and/or epigenetic. The cytokinesis block micronucleus (CBMN) and the alkaline single cell-gel electrophoresis 'Comet' assays were used to examine MCF-7 cells for chromosomal damage and DNA single-str...
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BACKGROUND Hydrogen peroxide (H(2)O(2)) is a common reactive oxygen intermediate generated by various forms of oxidative stress. AIM The aim of this study was to investigate the DNA damage capacity of H(2)O(2) in HepG2 cells. METHODS Cells were treated with H(2)O(2) at concentrations of 25 µM or 50 µM for 5 min, 30 min, 40 min, 1 h, or 24 h in parallel. The extent of DNA damage was assessed...
متن کاملResearch Article: Determination of genotoxic effects of aluminum on Cirrhinus mrigala and Ctenopharyngodon idella using comet assay and micronucleus test
Metals are the major pollutants in aquatic environment. A lot of research literature is available globally about accumulation of heavy metals in aquatic ecosystems as well as in different body organs of aquatic animals, especially fish. Heavy metals mainly generate reactive oxygen species (ROS) in aquatic animals that lead to oxidative stress production. ROS cause oxidative damage to different ...
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ژورنال
عنوان ژورنال: Mutagenesis
سال: 2005
ISSN: 1464-3804,0267-8357
DOI: 10.1093/mutage/gei026